Consider the following statements and select the correct option: A. The majority of CO₂ is transported by hemoglobin as carbaminohemoglobin. B. The binding of CO₂ to hemoglobin is inversely related to pO₂. C. Carbonic anhydrase is an enzyme that facilitates the formation of carbonic acid in the plasma. D. The release of O₂ from oxyhemoglobin is enhanced in tissues where metabolic activity is high.