How many of the given statements are correct regarding the ethical issues in biotechnology? 1. Manipulation of living organisms by humans cannot be done without regulation. 2. The Indian Parliament has recently cleared the second amendment of the Indian Patents Bill that takes such issues into consideration. 3. GEAC makes decisions regarding the validity of GM research and the safety of introducing GM organisms for public services. 4. Biopiracy refers to the use of bioresources by multinational companies and other organizations without proper authorisation from the countries and people concerned without compensatory payment.